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Introuction:

Chongqing Jiuding® Human Growth Hormone Fragment 176-191 (HGH Frag 176-191) is a lipolytic peptide fragment of human growth hormone. Human trials show that it retains the lipolytic properties of human growth hormone without stimulating IGF-1 production. Unlike human growth hormone, Human Growth Hormone Fragment 176-191 lowers blood sugar levels.

Chemical Structure of HGH Fragment 176-191:

 Objective:

To evaluate the anticancer efficacy of Chitosan nanoparticles loaded with human growth hormone hGH fragment 176-191 peptide plus the clinical chemotherapeutic doxorubicin in comparison with Chitosan loaded with doxorubicin alone.

Methods: 

Two sets of in silico experiments were performed using molecular docking simulations to determine the influence of hGH fragment 176-191 peptide on the anticancer efficacy of doxorubicin 1) the binding affinities of hGH fragment 176-191 peptide to the breast cancer receptors, 2) the effects of hGH fragment 176-191 peptide binding on doxorubicin binding to these same receptors. Further, the influence of hGH fragment 176-191 peptide on the anticancer efficacy of doxorubicin was validated using viability assay in Human MCF-7 breast cancer cells.

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